Pharmacology Quiz
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PRINCIPLES OF PHARMACOLOGY
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Tamoxifen is a pro-drug widely used for breast cancer treatment. Its efficacy is highly dependent on its conversion to the potent active metabolite, endoxifen, a reaction catalyzed primarily by CYP2D6. A patient on stable tamoxifen therapy is diagnosed with major depression. Which of the following antidepressant choices would pose the greatest risk of compromising her cancer treatment?
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