Pathophysiology Quiz
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RENAL AND FLUID BALANCE PATHOPHYSIOLOGY
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A patient with chronic kidney disease (CKD) initially presented with a normal anion gap metabolic acidosis. As their GFR declined from 45 mL/min to 15 mL/min over several years, their acidosis transitioned to a high anion gap type. What is the most likely pathophysiological explanation for this transition?
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