Pathophysiology Quiz
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MUSCULOSKELETAL AND INTEGUMENTARY PATHOPHYSIOLOGY
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In a poorly perfused, chronic wound, the normal healing cascade is disrupted. Despite the presence of inflammatory cells that should be releasing growth factors like Platelet-Derived Growth Factor (PDGF) and Vascular Endothelial Growth Factor (VEGF), target cells like fibroblasts and endothelial cells show a blunted response.
Which mechanism best explains the reduced efficacy of endogenous growth factors within the microenvironment of a chronic, infected, or ischemic wound?
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