Organic Chemistry 2 Quiz
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CARBONYL CHEMISTRY II: ACYL SUBSTITUTION
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The reactivity of a carboxylic acid derivative R-CO-L is inversely related to the basicity of its leaving group L⁻. Given the following pKa values for the conjugate acids (HL): H₂S (pKa=7.0), H₂O (pKa=15.7), CH₃COOH (pKa=4.8), NH₃ (pKa=38). Which derivative would be the LEAST reactive toward nucleophilic acyl substitution?
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