NAPLEX Quiz
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FOUNDATIONAL KNOWLEDGE FOR PHARMACY PRACTICE
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A 45-year-old man (110 kg) with major depressive disorder has inadequate response after 8 weeks of sertraline 200 mg daily and reports sexual dysfunction. You review a randomized, double-blind trial in adults with selective serotonin reuptake inhibitor partial response: adjunctive bupropion sustained-release 150 mg twice daily vs adjunctive aripiprazole 5–15 mg daily for 12 weeks; remission occurred in 28% vs 32% (risk difference 4%; 95% confidence interval −2% to 10%; p=0.18), while treatment-emergent sexual dysfunction improved in 41% vs 18% (p<0.001) and weight gain ≥5% occurred in 3% vs 15% (p<0.001). Based on the study, which treatment is most appropriate for this patient?
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