NAPLEX Quiz
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FOUNDATIONAL KNOWLEDGE FOR PHARMACY PRACTICE
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A 40-year-old White man (86 kg) with major depressive disorder is switching antidepressants due to persistent symptoms. Current medications include paroxetine 40 mg orally daily (for 8 weeks) and trazodone 50 mg orally at bedtime as needed for sleep; allergies: none; medical history includes generalized anxiety disorder and prior intolerable nausea with sertraline. Labs: serum creatinine 0.9 mg/dL (estimated creatinine clearance 110 mL/min), alanine aminotransferase 20 units/L. Pharmacogenomic testing shows CYP2D6 ultrarapid metabolizer. Which medication is most appropriate for this patient given their genetic profile?
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