Pharmacokinetics And Pharmacodynamics
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QUESTION
What is the definition of extraction ratio
E
E
E
for an eliminating organ?
QUESTION
State the formula for maintenance dosing rate to achieve target
C
s
s
C_{ss}
C
ss
(IV infusion).
QUESTION
State the formula for AUC after a single IV bolus dose with first-order elimination.
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ANSWER
A
U
C
=
Dose
C
L
AUC=\frac{\text{Dose}}{CL}
A
U
C
=
C
L
Dose
. For IV administration, AUC reflects total drug exposure as the ratio of dose to clearance in first-order elimination.
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