Pharmacokinetic Parameters
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QUESTION
What is the definition of volume of distribution (V or
V
d
V_d
V
d
)?
QUESTION
State the formula linking half-life, elimination rate constant, and natural log of
2
2
2
.
QUESTION
State the formula for half-life in terms of volume of distribution and clearance.
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ANSWER
t
1
2
=
0.693
×
V
C
L
t_{\frac{1}{2}} = \frac{0.693\times V}{CL}
t
2
1
=
C
L
0.693
×
V
. Half-life integrates volume of distribution and clearance, using the natural log of 2 to express time for 50% elimination.
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