Identify the disease state in which NSAIDs commonly worsen renal function and fluid status.
QUESTION
What is the interaction between rifampin and many CYP substrates (e.g., apixaban)?
QUESTION
What is the interaction between clopidogrel and omeprazole?
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ANSWER
CYP2C19 inhibition reduces clopidogrel activation. Omeprazole inhibits CYP2C19, impairing conversion of clopidogrel to its active metabolite and reducing antiplatelet efficacy.