Which condition is a contraindication to using nonselective beta-blockers in asthma?
QUESTION
What is the major contraindication for isotretinoin related to patient factors?
QUESTION
Which drug class is contraindicated with any nitrate therapy due to profound hypotension risk?
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ANSWER
PDE5 inhibitors (e.g., sildenafil, tadalafil, vardenafil). These drugs potentiate the vasodilatory effects of nitrates through cGMP accumulation, risking severe cardiovascular collapse.