Microbiology Quiz
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ANTIMICROBIALS AND RESISTANCE
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An investigational drug, FtsZ-inh, functions by binding to the GTPase domain of the FtsZ protein, locking it in a conformation that prevents its polymerization into the Z-ring required for bacterial cell division. A resistant mutant of E. coli is isolated that shows no changes in drug uptake or efflux. Sequencing of the ftsZ gene is performed. Which finding would be the most likely cause of resistance?
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