Microbiology Quiz
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ANTIMICROBIALS AND RESISTANCE
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The minimum inhibitory concentration (MIC) of sulfamethoxazole for a strain of E. coli is 32 µg/mL, and the MIC for trimethoprim is 2 µg/mL. In a checkerboard assay, bacterial growth is inhibited by a combination of 4 µg/mL of sulfamethoxazole and 0.25 µg/mL of trimethoprim. What pharmacological principle does this interaction demonstrate?
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