Microbiology Quiz
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HOST–MICROBE INTERACTIONS AND PATHOGENESIS
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A virulence factor in a Gram-negative bacterium is synthesized in the cytoplasm with an N-terminal signal sequence. It is first translocated across the inner membrane into the periplasm in an unfolded state by the Sec machinery, where it folds into its active conformation. Finally, a multi-protein complex in the outer membrane, known as the secretin, pushes the folded protein into the extracellular environment. This two-step mechanism is characteristic of which secretion system?
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