Microbiology Quiz
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HOST–MICROBE INTERACTIONS AND PATHOGENESIS
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During invasion of intestinal epithelial cells, Salmonella uses a Type III secretion system to inject the effector protein SopE. SopE functions as a guanine nucleotide exchange factor (GEF) for the host's Rho-family GTPases, including Cdc42 and Rac1. What is the direct downstream consequence of SopE's GEF activity that facilitates bacterial entry?
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