If a competitive inhibitor is present, how does increasing [S] affect inhibition at high [S]?
QUESTION
In Lineweaver–Burk plots, which inhibition type leaves the x-intercept (−Km1) unchanged?
QUESTION
In Lineweaver–Burk plots, which inhibition type leaves the y-intercept (Vmax1) unchanged?
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ANSWER
Competitive inhibition. In Lineweaver-Burk plots, competitive inhibition increases the slope and x-intercept shift, but Vmax is unchanged, so y-intercept remains the same.