Identify the mitochondrial event that commits a cell to intrinsic apoptosis.
QUESTION
Which caspases are initiator caspases in extrinsic and intrinsic pathways?
QUESTION
Identify the hallmark DNA change in apoptosis detected by TUNEL assay.
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ANSWER
Internucleosomal DNA fragmentation producing many free 3′-OH ends. Apoptotic endonucleases cleave DNA at internucleosomal sites, generating free 3′-OH ends detectable by TUNEL assay for labeling fragmented DNA.