Amino Acid Structure and Classification (1A)
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QUESTION
At pH
7.4
7.4
7.4
, which side chain is most likely to act as a general acid/base in enzyme active sites?
QUESTION
Identify the amino acid that is both polar and aromatic in standard MCAT classifications.
QUESTION
At pH
7.4
7.4
7.4
, which side chain is most likely to act as a general acid/base in enzyme active sites?
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ANSWER
Histidine. Its imidazole side chain has a pKa near 6.5, enabling proton donation or acceptance at physiological pH in catalysis.
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