Bio & Biochem Quiz
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FOUNDATIONAL CONCEPT 3: ORGAN SYSTEMS AND HOMEOSTASIS
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In a controlled experiment, a skeletal muscle fiber is exposed to a drug that selectively inhibits the sarcoplasmic reticulum Ca2+\text{Ca}^{2+}-ATPase (SERCA) by 80% without directly affecting ryanodine receptors, troponin, or myosin ATPase. A single muscle action potential is elicited. Assume resting cytosolic free Ca2+\text{Ca}^{2+} is ∼100 nM\sim 100\ \text{nM} and peak free Ca2+\text{Ca}^{2+} during a twitch is ∼10 μM\sim 10\ \mu\text{M} under control conditions. Which statement best describes the role of calcium in this process?
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