Bio & Biochem Quiz
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FOUNDATIONAL CONCEPT 3: ORGAN SYSTEMS AND HOMEOSTASIS
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In a study of synaptic integration, a neuron receives a train of identical excitatory presynaptic spikes at 50 Hz. Under control conditions, the postsynaptic potentials show temporal summation and eventually reach threshold. A drug is applied that increases postsynaptic membrane leak conductance (decreases input resistance) without changing synaptic receptor conductance or presynaptic release. What outcome would be expected?
Assume: membrane time constant τ=RmCm; higher leak conductance lowers Rm and reduces voltage change for a given synaptic current.
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