Bio & Biochem Quiz
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FOUNDATIONAL CONCEPT 2: CELLS AND CELLULAR ORGANIZATION
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In a tumor-derived cell line, investigators knocked down a kinetochore protein implicated in correcting improper microtubule attachments. During mitosis, fixed-cell analysis showed an increased frequency of lagging chromosomes during anaphase and formation of micronuclei in the subsequent interphase. Spindle poles appeared bipolar, and cells did not show gross spindle collapse.
Based on the study, which conclusion about the mitotic error is most consistent with the data?
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