Bio & Biochem Quiz
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FOUNDATIONAL CONCEPT 2: CELLS AND CELLULAR ORGANIZATION
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Cells exposed to a replication stressor activate the ATR/Chk1 pathway, which reduces origin firing and slows S-phase progression. In a tumor cell line, a researcher knocks down Chk1 and then repeats the replication stress. The Chk1-knockdown cells show increased DNA strand breaks and continue incorporating nucleotides at a high rate despite the stressor.
Which conclusion is most consistent with these results regarding checkpoint control in cancer?
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