Bio & Biochem Quiz
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FOUNDATIONAL CONCEPT 2: CELLS AND CELLULAR ORGANIZATION
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In a neurobiology experiment, neurons expressing normal levels of PrP are exposed to increasing concentrations of preformed prion fibrils. Investigators observe a dose-dependent increase in intracellular inclusions and decreased axonal transport of vesicles, while nuclear transcription profiles show relatively minor changes early in exposure. The inoculum is confirmed to be free of nucleic acids. Which statement most accurately describes the mechanism linking prion exposure to impaired axonal transport?
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