Bio & Biochem Quiz
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FOUNDATIONAL CONCEPT 2: CELLS AND CELLULAR ORGANIZATION
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A vascular physiology group studied how endothelial tissue organization affects blood flow regulation. Endothelium is a simple squamous epithelium lining blood vessels; its cells form a continuous monolayer with apical surfaces facing blood and basal surfaces contacting a basement membrane. In an ex vivo arteriole preparation, selective disruption of adherens junctions (cell–cell adhesion complexes linked to the actin cytoskeleton) increased leakage of a 70-kDa fluorescent dextran into surrounding tissue, but vessel diameter responses to a smooth-muscle vasoconstrictor were unchanged. Based on the passage, how does endothelium organization contribute to its function?
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