Bio & Biochem Quiz
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FOUNDATIONAL CONCEPT 1: BIOMOLECULES AND METABOLISM
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A physiology study (150–250 words) examined hepatocytes exposed to high citrate, modeling abundant mitochondrial export of acetyl-CoA equivalents in the fed state. Without changing insulin signaling, citrate addition decreased conversion of fructose-6-phosphate to fructose-1,6-bisphosphate and reduced lactate production. ATP levels were high.
Regulatory node: Fructose-6-phosphate PFK-1 Fructose-1,6-bisphosphate
Which outcome is most consistent with citrate-mediated regulation at this step?
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