Bio & Biochem Quiz
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FOUNDATIONAL CONCEPT 1: BIOMOLECULES AND METABOLISM
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Investigators culture primary hepatocytes and treat them with a selective inhibitor of fructose-1,6-bisphosphatase (FBPase-1). Cells are then provided lactate as the predominant carbon source (10 mM) in low-glucose medium (1 mM). The concept being tested is control of gluconeogenesis from lactate. Which outcome is most consistent with FBPase-1 inhibition in this setting?
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