Bio & Biochem Quiz
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FOUNDATIONAL CONCEPT 1: BIOMOLECULES AND METABOLISM
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In kidney collecting duct cells, a hormone rapidly increased water permeability of the apical membrane. Investigators used fluorescence microscopy to track vesicles containing a water channel protein (Channel W). Hormone treatment increased Channel W at the apical surface without changing total Channel W protein over 30 minutes. A mutant Channel W lacking a short C-terminal trafficking motif failed to accumulate apically after hormone exposure. Based on the scenario, which outcome is most consistent with Channel W's function?
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