Genetics Quiz
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DNA REPLICATION, REPAIR & MUTATION
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During proofreading, the exonuclease activity of DNA polymerase reverses the polymerization reaction to remove a misincorporated nucleotide. The catalytic activity involves a nucleophilic attack that cleaves a specific chemical bond. To restore a valid 3' primer terminus for continued synthesis, which bond must be broken by the exonuclease?
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