Genetics Quiz
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HUMAN AND MEDICAL GENETICS (INTRO)
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Infection with high-risk strains of human papillomavirus (HPV) is a primary cause of cervical cancer. The virus integrates into the host genome and expresses two key proteins, E6 and E7. The E6 protein binds to the p53 protein and targets it for ubiquitin-mediated degradation. The E7 protein binds to the retinoblastoma (Rb) protein and disrupts its interaction with the E2F transcription factor. How does the action of these viral proteins relate to the functions of oncogenes and tumor suppressors?
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