Genetics Quiz
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CHROMOSOMES, MEIOSIS & CYTOGENETICS
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A phenotypically normal woman has a karyotype of 45,XX,der(14;21)(q10;q10). She and her partner, who has a normal 46,XY karyotype, are seeking genetic counseling. Assuming random segregation of the relevant chromosomes during meiosis, what is the theoretical probability that their child will have Down syndrome as a result of an unbalanced translocation?
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