Genetics Quiz
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DATA INTERPRETATION & EXPERIMENTAL DESIGN
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In mice, the Igf2 gene is essential for normal growth. A mutant allele, Igf2-, results in a dwarf phenotype only when inherited from the father. If inherited from the mother, the mouse is normal-sized. This suggests paternal imprinting (maternal allele is silenced).
Which set of crosses provides the most direct and rigorous test for this specific pattern of imprinting?
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