Genetics Quiz
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HUMAN AND MEDICAL GENETICS (INTRO)
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A woman of Ashkenazi Jewish descent is concerned about her risk of being a carrier for Tay-Sachs disease. The carrier frequency in her population is 1/30. She has a negative enzyme-based carrier screen, which has a detection rate of >98%. Her partner is not of Ashkenazi Jewish descent and has a negative carrier screen. The carrier risk in his population is 1/300. What is the most significant factor in determining the couple's residual risk for an affected child?
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