Genetics Quiz
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GENE EXPRESSION
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The Fas gene produces two isoforms via alternative splicing of exon 6. Inclusion of exon 6 generates the transmembrane Fas receptor that induces apoptosis. Skipping of exon 6 produces a soluble, anti-apoptotic isoform. In activated T-cells, the pro-apoptotic transmembrane isoform predominates. What is the most direct molecular explanation for this cell-state-dependent splicing switch?
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