College Biology Quiz
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CELL SIGNALING & CELL CYCLE
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Read this context: The cell cycle is regulated by fluctuating cyclin levels that activate CDKs at specific times. Checkpoints at G1/S and G2/M act as safeguards: the first prevents replication of damaged DNA, and the second prevents mitosis if replication is incomplete. Tumor suppressors like p53 can enforce checkpoint pauses, while proto-oncogenes promote progression when signals are appropriate. If cyclin/CDK activity becomes too high, cells may pass checkpoints inappropriately and proliferate. How do cyclin-dependent kinases (CDKs) influence cell cycle progression?
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