Cell Biology Quiz
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CELL SIGNALING AND COMMUNICATION
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A researcher studies signaling in pancreatic islets and observes that alpha cells secrete glucagon in response to low glucose. This glucagon then: (1) enters the bloodstream and travels to the liver to stimulate glucose production, (2) diffuses locally within the islet to bind receptors on nearby beta cells within 30 micrometers, inhibiting their insulin secretion, and (3) binds to glucagon receptors on the same alpha cells that secreted it, creating a positive feedback loop that enhances further glucagon release. When the researcher uses a glucagon receptor antagonist that only blocks receptors on alpha cells (leaving beta cell and liver receptors functional), which signaling pathway(s) would be disrupted?
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