Cell Biology Quiz
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CELL SIGNALING AND COMMUNICATION
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A research team studying calcium signaling discovers that in certain cells, IP₃-induced calcium release from the ER can trigger additional calcium release through ryanodine receptors, a phenomenon called calcium-induced calcium release (CICR). They find that when cells are treated with ryanodine (which blocks ryanodine receptors), the peak calcium response to IP₃-generating stimuli is reduced by 60%, even though IP₃ levels are unchanged. What does this suggest about the relative contributions of IP₃ and ryanodine receptors to the total calcium response?
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