Cell Biology Quiz
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APPLIED CELL BIOLOGY AND DISEASE
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A gene therapy trial for X-linked severe combined immunodeficiency (X-SCID) uses a retroviral vector to deliver a functional IL2RG gene to patient T-cells ex vivo before reinfusion. Several patients develop leukemia years after treatment. Investigation reveals that the therapeutic vector integrated near the LMO2 oncogene in the leukemic cells. What mechanism most likely contributed to the development of leukemia?
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