Biochemistry Quiz
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CLINICAL AND APPLIED BIOCHEMISTRY
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A patient with a chronic viral infection is treated with a drug that is a competitive inhibitor of the viral protease enzyme. Initially, the treatment is effective. However, a drug-resistant strain of the virus emerges. Sequencing of the protease gene in the resistant strain reveals a single amino acid substitution. Which mutation is most likely to confer resistance to this specific drug while preserving the enzyme's catalytic function?
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