AP Biology Quiz
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CHEMISTRY OF LIFE
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A nucleotide triphosphate contains a nitrogenous base (N), a sugar (C, H, O), and three phosphate groups (P and O). Each phosphate group includes multiple oxygen atoms that carry negative charge at cellular pH, so the triphosphate region has strong electrostatic repulsion within the molecule and interacts strongly with water and cations. In contrast, the sugar and base region is less negatively charged. When a bond between two phosphates is broken, the products have reduced electrostatic repulsion compared with the reactant. Which molecular property best explains why the triphosphate region is relatively unstable?
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