Taste and Smell: Chemoreception - Anatomy and Physiology

  1. Which substance does the umami taste mainly detect?
    Glutamate (an amino acid), giving a savory taste.
  2. Which cranial nerve carries taste from the anterior two-thirds of the tongue?
    The facial nerve (CN VII), via the chorda tympani. The posterior third is served by the glossopharyngeal nerve (CN IX).
  3. Which tongue papillae lack taste buds?
    Filiform papillae. Fungiform, foliate and vallate papillae contain taste buds.
  4. Why must an odorant dissolve in nasal mucus before it can be smelled?
    Odorants must reach and bind receptor proteins on the cilia of olfactory neurons, which lie within the mucus layer.
  5. How does the olfactory pathway differ from other sensory pathways in reaching the cortex?
    It reaches the olfactory cortex and limbic areas without first relaying in the thalamus.
  6. What are the five basic taste qualities?
    Sweet, sour, salty, bitter, and umami.
  7. Which taste qualities are detected through G protein-coupled receptors?
    Sweet, bitter and umami. Salty and sour are detected mainly through ion channels (Na+ and H+).
  8. What type of cell are olfactory receptor cells, and how are they unusual?
    Bipolar neurons in the olfactory epithelium that are continually replaced from basal stem cells.
  9. A skull fracture damages the cribriform plate of the ethmoid bone. Which sense is most likely lost?
    Smell (anosmia), because olfactory nerve axons pass through the cribriform plate to the olfactory bulb.
  10. How do olfactory receptors transduce odorant binding into a signal?
    They are G protein-coupled receptors that raise cAMP, opening cation channels and depolarizing the neuron.
  11. Where is the primary gustatory cortex located?
    In the insula (with the adjacent frontal operculum).

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