Muscle Tissue: Skeletal, Cardiac, Smooth - Anatomy and Physiology

  1. Why do the cells of single-unit (visceral) smooth muscle contract together as a unit?
    Gap junctions electrically couple neighboring cells, so excitation spreads from cell to cell.
  2. What is the shape and nucleus arrangement of a smooth muscle cell?
    Spindle-shaped (tapered at both ends) with a single central nucleus.
  3. Which structures join cardiac muscle cells end to end?
    Intercalated discs, which contain gap junctions for electrical coupling and desmosomes for mechanical strength.
  4. Why can cardiac muscle not be tetanized?
    Its long refractory period lasts nearly as long as the contraction, so the cell relaxes before it can be restimulated.
  5. Which two muscle tissues are under involuntary control?
    Cardiac and smooth muscle. Skeletal muscle is the only voluntary type.
  6. Which calcium-binding protein in smooth muscle takes the role that troponin has in skeletal muscle?
    Calmodulin. Calcium-calmodulin activates myosin light chain kinase to start contraction.
  7. Which muscle tissue has striated, long cylindrical cells with many nuclei at the periphery?
    Skeletal muscle. Each fiber forms by the fusion of many embryonic cells.
  8. In smooth muscle, what structures anchor thin filaments in place of Z discs?
    Dense bodies.
  9. Which muscle tissue has branched striated cells, usually with one or two central nuclei?
    Cardiac muscle.
  10. Which cells allow limited regeneration of skeletal muscle after injury?
    Satellite cells, stem cells lying between the fiber and its endomysium.
  11. Which of the three muscle tissues has the greatest capacity to regenerate?
    Smooth muscle. Skeletal muscle regenerates only partly, and cardiac muscle very little.
  12. Which muscle tissue lacks striations?
    Smooth muscle. Its actin and myosin are not arranged in sarcomeres.

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