Test: GRE Subject Test: Biology

In eukaryotes, promoter sequences are regulatory elements found upstream of the transcription start site. Promoter sequences are required for transcription factors and RNA polymerase to recognize and bind to the DNA strand, thus promoting transcription of the genes on that strand and production of mRNA.

1.

mRNA is ultimately translated into proteins, i.e. gene products. Consider a mutation in the promoter sequence that increases the affinity of RNA polymerase for the DNA strand. Compared to a sequence where the promoter sequence is wild-type, which of the outcomes below is most likely for this mutated promoter region?

The process described above has nothing to do with quantity of gene product

Overexpression of the gene product

20% reduction in gene product

Loss of the gene product

Altered tertiary structure of the gene product

1/2 questions

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