Test: GRE Subject Test: Biology


Consider the following scenario:

Gene-Z is a transcription factor required for transcribing the genes that contribute to populating the motor cortex with the proper number of neurons. Mutant mice for Gene-Z have 50% fewer motor neurons than controls (non-mutants). You genetically engineer a transgenic DNA construct that acts as a dominant negative to Gene-Z.

You transfect an embryonic mouse brain with this dominant negative and measure that all motor neurons get and expressed this construct. What would you expect the number of neurons in the transfected brain to be if the dominant negative works with 100% efficacy, and a normal motor cortex has 100,000 cells in the region you are examining?

1/2 questions


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