MCAT Biology : Reactions with Nitrogen Compounds

Study concepts, example questions & explanations for MCAT Biology

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Example Questions

Example Question #1 : Reactions

Which of the following statements is true concerning the Hofmann elimination reaction?

Possible Answers:

The Zaitsev product is favored in the elimination reaction

The quaternary ammonium salt is a poor leaving group

The least substituted alkene is the major product in the reaction

The ammonium is eliminated following an E1 mechanism

Correct answer:

The least substituted alkene is the major product in the reaction

Explanation:

The Hofmann product is the most favored product in a Hofmann elimination reaction. The reaction follows an E2 mechanism, where a quaternary ammonium salt is able to be removed from a hydrocarbon, resulting in an alkene product. This reaction results in the least substituted alkene being the primary product.

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