GRE Subject Test: Biochemistry, Cell, and Molecular Biology : Help with DNA Repair Proteins

Study concepts, example questions & explanations for GRE Subject Test: Biochemistry, Cell, and Molecular Biology

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All GRE Subject Test: Biochemistry, Cell, and Molecular Biology Resources

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Example Questions

Example Question #1 : Help With Dna Repair Proteins

Upon a double-stranded DNA break, a cell can repair the DNA by resecting damaged DNA by nucleases and resynthesis of DNA by DNA polymerase. Next, DNA ligase binds the resynthesized fragment to the original DNA strand. What best describes this process? 

Possible Answers:

V(D)J recombination

Homologous recombination

Selective autophagy

Non-homologous end joining repair 

Homology-directed repair

Correct answer:

Non-homologous end joining repair 

Explanation:

The correct answer is non-homologous end joining repair. This type of DNA repair is more common than homology-directed repair which repairs damaged DNA by using a homologous template. Homologous recombination is a specific type of homology-directed repair. V(D)J recombination is a form of genetic recombination that occurs in developing lymphocytes to give rise to diverse antibodies. Selective autophagy is the selective removal of damaged proteins from the cell following a stress event such as heat exposure. 

Example Question #1 : Help With Dna Repair Proteins

DNA ligase IV has been studied for its role in what process specifically?

Possible Answers:

None of the other answers 

Homologous recombination

Non-homologous end joining DNA repair

Homology directed DNA repair

DNA replication of lagging strand

Correct answer:

Non-homologous end joining DNA repair

Explanation:

The correct answer is non-homologous end joining DNA repair. This specific DNA ligase joins the double stranded phosphodiester bond break in DNA by consumption of ATP, however, this repair mechanism often times is error prone and results in indels (insertion/deletion mutations). Homology directed DNA repair and homologous recombination are very similar processes that rely on template sequences to "swap" DNA sequences with other parts of the genome, however, they do not rely on this ligase. DNA ligase IV does not have a role in DNA replication. 

Example Question #3 : Help With Dna Repair Proteins

Primase is an enzyme that synthesize small primers for DNA polymerase to bind to so it can initiate DNA replication. What are these primers made of?

Possible Answers:

Carbohydrates

RNA

Lipids

Protein

DNA

Correct answer:

RNA

Explanation:

Primase synthesizes RNA primers for DNA polymerase to bind to and initiate DNA replication.

All GRE Subject Test: Biochemistry, Cell, and Molecular Biology Resources

1 Diagnostic Test 201 Practice Tests Question of the Day Flashcards Learn by Concept
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