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Test: MCAT Biology
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the loss of tolerance to self antigens leading to the presence of high autoantibody titers. There are several underlying causes behind SLE, one of which is a dysregulation in the clearance of apoptotic cells, which can lead to secondary necrosis. This leads to the leakage of danger signals which contributes to the loss of peripheral tolerance and chronic inflammation.
1. | A deficiency in the clearance of apoptotic cells can be attributed to which immune cell type? |
Germinal center B cells
Macrophages
Plasma cells
Cytotoxic T cells
Natural killer cells
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